양성 및 악성 타액선 근상피종: 증례보고 및 면역조직화학적 연구
Benign and malignant myoepitheliomas in salivary gland: cases report and immunohistochemical study
변준호, 김종렬, 박봉욱, 이종실,
소속 상세정보
변준호 ( Byun June-Ho ) - 경상대학교 의학전문대학원 치과학교실 구강악안면외과
김종렬 ( Kim Jong-Ryoul ) - 부산대학교 치의학전문대학원 구강악안면외과학교실
박봉욱 ( Park Bong-Wook ) - 경상대학교 의과대학 구강악안면외과학교실
이종실 ( Lee Jong-Sil ) - 경상대학교 의학전문대학원 병리학교실
KMID : 0360120090310010071
Abstract
Benign myoepithelioma (BME) and malignant myoepithelioma (MME) of the salivary gland are very rare and its biologic behavior has not been clarified fully. Although, cases reports for BME and MME were increased in recent, their diagnostic criteria were not completely established. We describe herein a case of BME of the parotid gland and a case of MME of the palatal minor gland, respectively. Histologically, multinodular growth pattern, infiltration to adjacent tissues, and hyalinized and myxoid matrix were observed in MME, that were different histologic features compared with BME. Strong immunoreactivities for the S-100 protein and vimentin were detected in the tumor cells of BME and MME. In specimen of MME, moderately expressed p53 and strongly expressed p63 were detected. However, in specimen of BME, p53 was negatively and p63 was weakly expressed, respectively. In conclusion, the expression patterns of p53 and p63 as well as histologic aggressiveness might be used to diagnose the MME.
키워드
Benign myoepithelioma;Malignant myoepithelioma;Immunohistochemical study
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